Anti-Cubilin CUBN Rabbit Monoclonal Antibody | Boster M03670-1 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Cubilin CUBN Rabbit Monoclonal Antibody

catalog :

M03670-1

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

EF-3

reactivity :

human, mouse, rat

application :

western blot

product information

SKU :

M03670-1

Product Name :

Anti-Cubilin CUBN Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

EF-3

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

Application Details :

WB 1:500-1:2000

Description :

Boster Bio Anti-Cubilin CUBN Rabbit Monoclonal Antibody catalog # M03670-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CUBN

Uniprot ID :

O60494

Immunogen :

A synthesized peptide derived from human Cubilin

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Cubilin

Synonyms :

Cubilin; 460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor; CUBN; IFCR;

Molecular Weight :

398736 MW

Protein Function :

Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.

Subcellular Localization :

Apical cell membrane ; Peripheral membrane protein. Cell membrane ; Peripheral membrane protein. Membrane, coated pit. Endosome. Lysosome membrane ; Peripheral membrane protein. Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.

Tissue Specificity :

Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.

Research Category :

Cancer, Cancer Metabolism, Cofactors, Vitamins / Minerals, Endocrine Metabolism, Hormone Biosynthesis, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Lipids And Lipoproteins, Pathways And Processes, Signal Transduction, Vitamins / Minerals