Anti-Human Stefin B DyLight® 550 conjugated CSTB Antibody(monoclonal, 2B6)

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Human Stefin B DyLight® 550 conjugated CSTB Antibody(monoclonal, 2B6)

catalog :

M02794-Dyl550

quantity :

50 ug/vial

clonality :

monoclonal

host :

mouse

conjugate :

DyLight 550

reactivity :

human

application :

flow cytometry

product information

SKU :

M02794-Dyl550

Product Name :

Anti-Human Stefin B DyLight® 550 conjugated CSTB Antibody(monoclonal, 2B6)

Size :

50 ug/vial

Clonality :

Monoclonal

Host :

Mouse

Conjugate :

DyLight®550

Reactivity :

Human

Application(s) :

Flow Cytometry

Application Details :

Flow Cytometry, 1-3μg/1x10^6 cells

Description :

Boster Bio Anti-Human Stefin B DyLight® 550 conjugated CSTB Antibody (monoclonal, 2B6) catalog # M02794-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CSTB

Uniprot ID :

P04080

Immunogen :

E. coli-derived human Stefin B recombinant protein (Position: M1-F98). Human Stefin B shares 78.6 % amino acid (aa) sequence identity with both mouse and rat Stefin B.

Form :

Liquid

Contents :

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Cross-reactivity :

No cross reactivity with other proteins.

Isotype :

IgG1

Storage :

At 2-8?C for one year from date of receipt. Protect from light. Do not freeze.

Gene Full Name :

cystatin B (stefin B)

Synonyms :

Cystatin-B; CPI-B; Liver thiol proteinase inhibitor; Stefin-B; CSTB; CST6; STFB

Protein Function :

This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.

Subcellular Localization :

Cytoplasm

Background :

Cystatin B (CSTB), also called STFB, is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The cystatin B gene is located on 21q22.3. It is widely distributed and is localized mostly intracellularly, but has been found extracellularly. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is thought to be as a protector against the proteinases leaking from lysosomes. A cystatin B multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, CSTB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of CSTB is dependent on the differentiation status of the cell.

Research Category :

Cell Biology, Protease Inhibitors, Proteolysis / Ubiquitin