Anti-SETD7/Set7 Rabbit Monoclonal Antibody | Boster M02793 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-SETD7/Set7 Rabbit Monoclonal Antibody

catalog :

M02793

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

ABA-19

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

product information

SKU :

M02793

Product Name :

Anti-SETD7/Set7 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

ABA-19

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, IP

Application Details :

WB 1:500-1:2000 .IP 1:50

Description :

Boster Bio Anti-SETD7/Set7 Rabbit Monoclonal Antibody catalog # M02793. Tested in IP, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

SETD7

Uniprot ID :

Q8WTS6

Immunogen :

A synthesized peptide derived from human SETD7

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Histone-lysine N-methyltransferase SETD7

Synonyms :

Histone-lysine N-methyltransferase SETD7; 2.1.1.43; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9; SETD7; KIAA1717, KMT7, SET7, SET9;

Molecular Weight :

40721 MW

Protein Function :

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Subcellular Localization :

Nucleus. Chromosome.

Tissue Specificity :

Widely expressed. Expressed in pancreatic islets.

Research Category :

ChIP’ing Antibodies, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Methylation