Anti-VE-Cadherin-5 Cdh5-Rabbit Monoclonal Antibody | Boster M02632 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-VE-Cadherin-5 Cdh5-Rabbit Monoclonal Antibody

catalog :

M02632

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

IIC-3

reactivity :

mouse

application :

western blot, immunocytochemistry, immunoprecipitation

product information

SKU :

M02632

Product Name :

Anti-VE-Cadherin-5 Cdh5-Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

IIC-3

Host :

Rabbit

Reactivity :

Mouse

Application(s) :

IP, IF, ICC, WB

Application Details :

WB 1:500~1:1000 .ICC/IF 1:500~1:1000 .IP 1:50

Description :

Boster Bio Anti-VE-Cadherin-5 Cdh5-Rabbit Monoclonal Antibody catalog # M02632. Tested in IP, IF, ICC, WB applications. This antibody reacts with Mouse.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

Cdh5

Uniprot ID :

P55284

Immunogen :

A synthesized peptide derived from mouse VE Cadherin

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Cadherin-5

Synonyms :

Cadherin-5; Vascular endothelial cadherin; VE-cadherin; CD144; Cdh5;

Molecular Weight :

87903 MW

Protein Function :

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Subcellular Localization :

Cell junction. Cell membrane ; Single-pass type I membrane protein. Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions (By similarity).

Research Category :

Atherosclerosis, Cadherins, Cancer, Cardiovascular, Cell Adhesion, Cell Adhesion Molecules, Cytoskeleton / Ecm, Invasion/Microenvironment, Signal Transduction, Vascular Inflammation, Vasculature