Anti-SIRT5/Sirtuin 5 Rabbit Monoclonal Antibody | Boster M02395 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-SIRT5/Sirtuin 5 Rabbit Monoclonal Antibody

catalog :

M02395

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

HHE-19

reactivity :

human, mouse

application :

western blot

product information

SKU :

M02395

Product Name :

Anti-SIRT5/Sirtuin 5 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

HHE-19

Host :

Rabbit

Reactivity :

Human, Mouse

Application(s) :

Application Details :

WB 1:1000-1:2000

Description :

Boster Bio Anti-SIRT5/Sirtuin 5 Rabbit Monoclonal Antibody catalog # M02395. Tested in WB applications. This antibody reacts with Human, Mouse.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

SIRT5

Uniprot ID :

Q9NXA8

Immunogen :

A synthesized peptide derived from human SIRT5

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

NAD-dependent protein deacylase sirtuin-5, mitochondrial

Synonyms :

NAD-dependent protein deacylase sirtuin-5, mitochondrial ; 3.5.1.- ; Regulatory protein SIR2 homolog 5 ; SIR2-like protein 5 ; SIRT5 ; SIR2L5;

Molecular Weight :

33881 MW

Protein Function :

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Subcellular Localization :

Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.

Tissue Specificity :

Widely expressed.

Research Category :

Acetylation, Cancer, Cardiovascular, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Metabolism