Anti-LGR4/Gpr48 Monoclonal Antibody | Boster M02134 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

other

product name :

Anti-LGR4/Gpr48 Monoclonal Antibody

catalog :

M02134

quantity :

100 uL

product information

sku :

M02134

status :

Enabled

name :

Anti-LGR4/Gpr48 Monoclonal Antibody

category name :

Primary Antibodies, Monoclonal Antibodies, IHC ICC IF Antibodies

gene name :

LGR4

price various sizes :

25ug sample size / $99 100uL / $339 100uL+Free HRP Secondary BA1050 / $339 100uL+Free Biotin Secondary BA1001 / $339

clonality :

Monoclonal

clone number :

6G8.B3.G5.C3

concentration :

1.13 mg/mL by UV absorbance at 280 nm

conjugate :

contents :

0.02 M Potassium Phosphate. 0.15 M Sodium Chloride. pH 7.2. 0.01% (w/v) Sodium Azide

description :

Monoclonal 6G8.B3.G5.C3 IgG2b kappa antibody for GPR48/LGR4 detection. Host: Mouse.Size: 100uL. Tested applications: IHC. Reactive species: Human. GPR48/LGR4 information: Molecular Weight: 104475 MW; Subcellular Localization: Cell membrane ; Multi-pass membrane protein ; Tissue Specificity: Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.

short description :

Anti-LGR4 Antibody validated for WB in Human.

size :

100 uL

sample size available :

25ug for $99, contact us for details

uniprot id :

Q8N537

host :

Mouse

immunogen :

This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human LGR4 protein.

form :

Liquid

purification :

Protein A purified

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time. Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins.

isotype :

Mouse IgG2b

application details :

Western Blot, 1:500 - 1:3, 000, human, chimpanzee, macaque. Direct ELISA, 1:20, 000 - 1:100, 000, human, chimpanzee, macaque. Immunohistochemistry: 5ug/mL, human, chimpanzee, macaque.

applications :

IHC, WB

reactivity :

Human

predicted reactivity :

Chimpanzee, Macaque

image labels :

LGR4 was detected in paraffin-embedded sections of human cerebellum tissues (A) and human Pancreas islet tissues (B) using mouse anti- LGR4 Antigen Affinity purified monoclonal antibody (Catalog # M02134) at 5 ug/mL. Personal communication, Andrew Elston, Lifespan Biosciences, Seattle, WA.

competitor equivalent skus :

sc 68579 sc 68578 sc 292344 sc 390630

research category :

G Protein Signaling, Signal Transduction, Signaling Pathway

synonyms :

Leucine-rich repeat-containing G-protein coupled receptor 4;G-protein coupled receptor 48;LGR4;GPR48;

gene full name :

Leucine-rich repeat-containing G-protein coupled receptor 4

molecular weight :

104475 MW

protein function :

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).

subcellular localization :

Cell membrane ; Multi-pass membrane protein .

tissue specificity :

Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.

last modified :

1/28/19 19:39