Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275 | Boster M02068-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275

catalog :

M02068-1

quantity :

100 uL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM275

The same clone is also sold as:

Invitrogen: MA5-27948
Abnova: MAB14922

reactivity :

human

application :

western blot, immunohistochemistry

product information

SKU :

M02068-1

Product Name :

Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275

Size :

100 uL

Clonality :

Monoclonal

Clone Number :

RM275

Host :

Rabbit

Reactivity :

Human

Application(s) :

WB, IHC

Application Details :

Immunohistochemistry (IHC): 1:2000-1:10000 dilution; Western Blot (WB): 1:250-1:1000 dilution.

Description :

Boster Bio Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275 catalog # M02068-1. Tested in IHC, WB applications. This antibody reacts with Human.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

F11R

Uniprot ID :

Q9Y624

Immunogen :

A peptide corresponding to the N-terminus of human human JAM1 (Junctional adhesion molecule 1).

Contents :

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Junctional adhesion molecule A

Synonyms :

Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD321; F11R; JAM1, JCAM; UNQ264/PRO301;

Molecular Weight :

32583 MW

Protein Function :

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).

Subcellular Localization :

Cell junction, tight junction. Cell membrane ; Single-pass type I membrane protein. Localized at tight junctions of both epithelial and endothelial cells.

Tissue Specificity :

Expressed in endothelium, epithelium and leukocytes (at protein level).

Research Category :

Atherosclerosis, Cardiovascular, Cell Adhesion, Cytoskeleton / Ecm, Platelets, Signal Transduction, Tight Junctions, Vascular Inflammation