Anti-Ubiquitin D UBD Rabbit Monoclonal Antibody | Boster M01970 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Ubiquitin D UBD Rabbit Monoclonal Antibody

catalog :

M01970

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

HID-21

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

product information

SKU :

M01970

Product Name :

Anti-Ubiquitin D UBD Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

HID-21

Host :

Rabbit

Reactivity :

Human, Mouse

Application(s) :

IF, IHC, ICC, WB

Application Details :

WB 1:500-1:1000 .IHC 1:50-1:200 .ICC/IF 1:50-1:200

Description :

Boster Bio Anti-Ubiquitin D UBD Rabbit Monoclonal Antibody catalog # M01970. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

UBD

Uniprot ID :

O15205

Immunogen :

A synthesized peptide derived from human Ubiquitin D

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Ubiquitin D

Synonyms :

Ubiquitin D; Diubiquitin; Ubiquitin-like protein FAT10; UBD; FAT10;

Molecular Weight :

18473 MW

Protein Function :

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN).

Subcellular Localization :

Nucleus. Cytoplasm. Accumulates in aggresomes under proteasome inhibition conditions.

Tissue Specificity :

Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland.

Research Category :

Cell Biology, Defensin, Human Protein, Immunology, Microbiology, Proteasome / Ubiquitin, Protein, Proteolysis / Ubiquitin, Secreted Molecules, Ub-Like Proteins