Anti-Desmin (DESM) Rabbit Monoclonal Antibody, Clone#RM234

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Desmin (DESM) Rabbit Monoclonal Antibody, Clone#RM234

catalog :

M01948-2

quantity :

100 ul

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM234

The same clone is also sold as:

Abnova: MAB15124
Bio-Rad: MCA6300
Invitrogen: MA5-33065
Novus Biologicals: NBP2-61527

reactivity :

human

application :

western blot, immunohistochemistry

product information

SKU :

M01948-2

Product Name :

Anti-Desmin (DESM) Rabbit Monoclonal Antibody, Clone#RM234

Size :

100 ul

Clonality :

Monoclonal

Clone Number :

RM234

Host :

Rabbit

Reactivity :

Human, Mouse

Application(s) :

WB, IHC

Application Details :

Immunohistochemistry (IHC): 1:1000-1:4000 dilution; Western Blot (WB): 1:1000-1:2000 dilution.

Description :

Boster Bio Anti-Desmin (DESM) Rabbit Monoclonal Antibody, Clone#RM234 catalog # M01948-2. Tested in IHC, WB applications. This antibody reacts with Human, Mouse.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

DES

Uniprot ID :

P17661

Immunogen :

A peptide corresponding to human Desmin

Contents :

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Desmin

Synonyms :

Desmin; DES;

Molecular Weight :

53536 MW

Protein Function :

Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity).

Subcellular Localization :

Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm. Cell membrane, sarcolemma. Nucleus. Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (PubMed:24200904, PubMed:26724190). Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes (By similarity).

Research Category :

Complement, Immunology, Innate Immunity