Anti-HTRA2/Omi Rabbit Monoclonal Antibody | Boster M01941 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-HTRA2/Omi Rabbit Monoclonal Antibody

catalog :

M01941

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

EEH-8

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

product information

SKU :

M01941

Product Name :

Anti-HTRA2/Omi Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

EEH-8

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

IP, IHC, WB

Application Details :

WB 1:500-1:2000 .IHC 1:50-1:200 .IP 1:30

Description :

Boster Bio Anti-HTRA2/Omi Rabbit Monoclonal Antibody catalog # M01941. Tested in IP, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

HTRA2

Uniprot ID :

O43464

Immunogen :

A synthesized peptide derived from human HTRA2

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Serine protease HTRA2, mitochondrial

Synonyms :

Serine protease HTRA2, mitochondrial; 3.4.21.108; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI; HTRA2; OMI, PRSS25;

Molecular Weight :

48841 MW

Protein Function :

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Subcellular Localization :

Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

Tissue Specificity :

Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

Research Category :

Apoptosis, Cancer, Cell Biology, Cell Death, Invasion/Microenvironment, Metabolism, Metabolism Processes, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Oxidative Stress, Pathways And Processes, Redox Metabolism