Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody | Boster M01595 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody

catalog :

M01595

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

GOA-14

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

product information

SKU :

M01595

Product Name :

Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

GOA-14

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

IP, WB

Application Details :

WB 1:5000-1:20000 .IP 1:50

Description :

Boster Bio Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody catalog # M01595. Tested in IP, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

NEDD4L

Uniprot ID :

Q96PU5

Immunogen :

A synthesized peptide derived from human NEDD4-2

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

E3 ubiquitin-protein ligase NEDD4-like

Synonyms :

E3 ubiquitin-protein ligase NEDD4-like; 6.3.2.-; NEDD4.2; Nedd4-2; NEDD4L; KIAA0439, NEDL3;

Molecular Weight :

111932 MW

Protein Function :

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Subcellular Localization :

Cytoplasm. May be recruited to exosomes by NDFIP1.

Tissue Specificity :

Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597). Expressed in melanocytes (PubMed:23999003).

Research Category :

Cell Biology, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Proteasome / Ubiquitin, Proteolysis / Ubiquitin, Ubiquitin E3 Enzymes