Anti-RON Rabbit Monoclonal Antibody | Boster M01532 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-RON Rabbit Monoclonal Antibody

catalog :

M01532

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

GFE-13

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

product information

SKU :

M01532

Product Name :

Anti-RON Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

GFE-13

Host :

Rabbit

Reactivity :

Human

Application(s) :

Flow Cytometry, IP, IF, IHC, ICC, WB

Application Details :

WB 1:1000-1:2000 .IHC 1:50-1:200 .ICC/IF 1:50-1:200 .IP 1:30 .Flow Cytometry 1:30

Description :

Boster Bio Anti-RON Rabbit Monoclonal Antibody catalog # M01532. Tested in Flow Cytometry, IP, IF, IHC, ICC, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

MST1R

Uniprot ID :

Q04912

Immunogen :

A synthesized peptide derived from human RON

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Macrophage-stimulating protein receptor

Synonyms :

Macrophage-stimulating protein receptor; MSP receptor; 2.7.10.1; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MST1R; PTK8, RON;

Molecular Weight :

152271 MW

Protein Function :

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Expressed in colon, skin, lung and bone marrow.

Research Category :

Cell Biology, Cell Cycle, Kinases/Phosphatases, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tyrosine Kinases