antibody

Anti-CD31 (PECAM-1) Rabbit Monoclonal Antibody, Clone#RM247

M01513-3

100 ul

monoclonal

domestic rabbit

nonconjugated

RM247

The same clone is also sold as:

• Invitrogen: MA5-33063
• Abnova: MAB15129

western blot, immunohistochemistry

Anti-CD31 (PECAM-1) Rabbit Monoclonal Antibody, Clone#RM247

100 ul

Monoclonal

RM247

Rabbit

Human

WB, IHC

Immunohistochemistry (IHC): 1:1000-1:2500 dilution; Western Blot (WB): 1:1000-1:2000 dilution.

Boster Bio Anti-CD31 (PECAM-1) Rabbit Monoclonal Antibody, Clone#RM247 catalog # M01513-3. Tested in IHC, WB applications. This antibody reacts with Human.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

PECAM1

P16284

A peptide corresponding to the cytoplasmic domain of human CD31

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Platelet endothelial cell adhesion molecule

Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD31; PECAM1;

82536 MW

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock- induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).

Cell membrane ; Single-pass type I membrane protein. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.

Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).

Angiogenesis, Cardiovascular, Cell Adhesion, Cell Adhesion Molecules, Cell Type Markers, Cytoskeleton / Ecm, Immunology, Signal Transduction