Anti-CDK8 Rabbit Monoclonal Antibody | Boster M01493 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-CDK8 Rabbit Monoclonal Antibody

catalog :

M01493

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

GHF-3

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

product information

SKU :

M01493

Product Name :

Anti-CDK8 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

GHF-3

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, IP

Application Details :

WB 1:500-1:1000 .IP 1:50

Description :

Boster Bio Anti-CDK8 Rabbit Monoclonal Antibody catalog # M01493. Tested in IP, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CDK8

Uniprot ID :

P49336

Immunogen :

A synthesized peptide derived from human CDK8

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Cyclin-dependent kinase 8

Synonyms :

Cyclin-dependent kinase 8; 2.7.11.22; 2.7.11.23; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35; CDK8;

Molecular Weight :

53284 MW

Protein Function :

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

Subcellular Localization :

Nucleus.

Research Category :

Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling, Kinases/Phosphatases, Mediator Complex, Transcription