Anti-Ms CD154 Purified CD40LG Monoclonal Antibody | Boster M01114-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Ms CD154 Purified CD40LG Monoclonal Antibody

catalog :

M01114-1

quantity :

0.1 mg (C100)

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

MR-1

The same clone is also sold as:

Invitrogen: 48-1541-82, HMCD15404, 16-1541-82, MA5-48163, 63-1541-82, 62-1541-82, 13-1541-82, 53-1541-82, 13-1541-85, 25-1541-82, 62-1541-80, 46-1541-80, 17-1541-82, HMCD15401, 16-1541-85, 12-1541-82, MA1-10108, BMS172, 12-1541-83, 12-1541-81, 61-1541-80, 46-1541-82, 17-1541-81, 61-1541-82
ichorbio: ICH1072UL, ICH1072
OriGene: AM08043LE-N, AM08043FC-N, AM08043BT-N, AM08043RP-N, AM08043PU-N
Abnova: MAB3231, RAB03276, RAB03277, MAB5719, MAB5718
Bio X Cell: BE0017-1-1MG, BE0017-1-100MG, BE0017-1-5MG, BE0017-1-25MG, BE0017-1-50MG
Exbio: 12-629-C100, 11-629-C100, 11-629-C025, 1F-629-C100, 1F-629-C025
BD Biosciences: 553658, 553655, 553656, 553657
Absolute Antibody: Ab01087-1.32, Ab01087-2.3, Ab01087-2.0, Ab01087-23.0, Ab01087-22.0
Abcam: ab24934, ab25568
BioLegend: 106519, 106503, 106509, 106505, 106517, 106520, 106518, 106506, 106512, 106514, 106513, 106515, 106510, 106511, 106516
Rockland Immunochemicals: 200-B08-N91, 200-B26-N91

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

product information

SKU :

M01114-1

Product Name :

Anti-Ms CD154 Purified CD40LG Monoclonal Antibody

Size :

0.1 mg (C100)

Clonality :

Monoclonal

Clone Number :

MR-1

Host :

Hamster

Reactivity :

Mouse

Application(s) :

Flow Cytometry, IP, IHC, ICC

Application Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-Ms CD154 Purified CD40LG Monoclonal Antibody catalog # M01114-1. Tested in Flow Cytometry, IP, IHC, ICC applications. This antibody reacts with Mouse.

Concentration :

1 mg/ml

Gene Name :

CD40LG

Uniprot ID :

P29965

Immunogen :

Activated mouse Th1 clone D1.6

Form :

Liquid

Contents :

Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Purification :

Purified by protein-A affinity chromatography

Isotype :

Armenian Hamster IgG1

Storage :

Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.

Gene Full Name :

ubiquitin specific peptidase 15

Synonyms :

Ubiquitin carboxyl-terminal hydrolase 15; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4; USP15; KIAA0529

Protein Function :

Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery. (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Subcellular Localization :

Mitochondrion. Nucleus. Cytoplasm.

Tissue Specificity :

Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for ICC.

Background :

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene. It is mapped to 12q14.1. This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.