Anti-CD41 ITGA2B Rabbit Monoclonal Antibody | Boster M01102 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-CD41 ITGA2B Rabbit Monoclonal Antibody

catalog :

M01102

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

AAGH-9

reactivity :

human

application :

western blot

product information

SKU :

M01102

Product Name :

Anti-CD41 ITGA2B Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

AAGH-9

Host :

Rabbit

Reactivity :

Human

Application(s) :

Application Details :

WB 1:500-1:1000 .IHC 1:50-1:200

Description :

Boster Bio Anti-CD41 ITGA2B Rabbit Monoclonal Antibody catalog # M01102. Tested in WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

ITGA2B

Uniprot ID :

P08514

Immunogen :

A synthesized peptide derived from human CD41

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Integrin alpha-IIb

Synonyms :

Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2; ITGA2B; GP2B, ITGAB;

Molecular Weight :

113377 MW

Protein Function :

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.

Research Category :

Angiogenesis, Cardiovascular, Cell Adhesion, Cell Type Markers, Cytoskeleton / Ecm, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Platelets, Signal Transduction, Stem Cells