Anti-EDNRB Antibody Picoband™ (monoclonal, 15C3) | Boster M01041-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-EDNRB Antibody Picoband™ (monoclonal, 15C3)

catalog :

M01041-1

quantity :

100µg/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

15C3

The same clone is also sold as:

Invitrogen: MA5-49181

reactivity :

human

application :

western blot

product information

SKU :

M01041-1

Product Name :

Anti-EDNRB Antibody Picoband™ (monoclonal, 15C3)

Size :

100µg/vial

Clonality :

Monoclonal

Clone Number :

15C3

Host :

Mouse

Reactivity :

Human

Application(s) :

Application Details :

Western blot, 0.1-0.5µg/ml.

Description :

Boster Bio Anti-EDNRB Antibody Picoband™ (monoclonal, 15C3) catalog # M01041-1. Tested in WB applications. This antibody reacts with Human.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

EDNRB

Uniprot ID :

P24530

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human EDNRB (406-439aa QSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKY), different from the related mouse and rat sequences by one amino acid.

Form :

Lyophilized

Contents :

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Cross-reactivity :

No cross reactivity with other proteins.

Isotype :

IgG2b

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500µg/ml.

Gene Full Name :

endothelin receptor type B

Synonyms :

Endothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type; EDNRB; ETRB

Protein Function :

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular Localization :

Cell membrane. Multi-pass membrane protein.

Tissue Specificity :

Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot.

Background :

Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Category :

G Protein Signaling, Signal Transduction, Signaling Pathway