Anti-Tyrosine-protein kinase Tec Tec Monoclonal Antibody

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Tyrosine-protein kinase Tec Tec Monoclonal Antibody

catalog :

M01031

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A5

The same clone is also sold as:

OriGene: AM06363SU-N
MyBioSource: MBS850954
Invitrogen: MA5-15546
Abnova: MAB10371

reactivity :

human

application :

western blot, ELISA

product information

SKU :

M01031

Product Name :

Anti-Tyrosine-protein kinase Tec Tec Monoclonal Antibody

Size :

100 ul

Clonality :

Monoclonal

Clone Number :

3A5

Host :

Mouse

Reactivity :

Human

Application(s) :

WB, ELISA

Application Details :

WB 1:500-1:2000 ELISA 1:10000

Description :

Boster Bio Anti-Tyrosine-protein kinase Tec Tec Monoclonal Antibody catalog # M01031. Tested in ELISA, WB applications. This antibody reacts with Human.

Concentration :

1 mg/ml

Gene Name :

TEC

Uniprot ID :

P42680

Immunogen :

Purified recombinant fragment of Tec expressed in E. Coli.

Form :

Liquid

Contents :

Ascitic fluid containing 0.03% sodium azide.

Purification :

Affinity purification

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Glutamate receptor ionotropic, NMDA 2B

Synonyms :

Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B

Protein Name :

Glutamate receptor ionotropic, NMDA 2B

Molecular Weight :

166367 MW

Protein Function :

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg (2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).

Subcellular Localization :

Cell membrane

Tissue Specificity :

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.