Anti-BCMA Tnfrsf17 Antibody (Monoclonal, Vicky-2) | Boster M01014 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-BCMA Tnfrsf17 Antibody (Monoclonal, Vicky-2)

catalog :

M01014

quantity :

100µg/vial

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

Vicky-2

The same clone is also sold as:

Abnova: MAB3374

reactivity :

mouse

application :

western blot, immunoprecipitation

product information

SKU :

M01014

Product Name :

Anti-BCMA Tnfrsf17 Antibody (Monoclonal, Vicky-2)

Size :

100µg/vial

Clonality :

Monoclonal

Clone Number :

Vicky-2

Host :

Rat

Reactivity :

Mouse

Application(s) :

IP, WB

Application Details :

WB, 1:1, 000, Mouse.IP, 1:200, Mouse

Description :

Boster Bio Anti-BCMA Tnfrsf17 Antibody (Monoclonal, Vicky-2) catalog # M01014. Tested in IP, WB applications. This antibody reacts with Mouse.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

Tnfrsf17

Uniprot ID :

O88472

Immunogen :

Recombinant mouse BCMA extracellular domain (aa 1-46).

Form :

Liquid

Contents :

Each vial contains 0.02% sodium azide.

Purification :

Protein G-affinity purified.

Cross-reactivity :

No cross reactivity with other proteins.

Gene Full Name :

Tumor necrosis factor receptor superfamily member 17

Synonyms :

Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; Tnfrsf17; Bcm, Bcma;

Protein Name :

Tumor necrosis factor receptor superfamily member 17 (Tnfrsf17)

Molecular Weight :

20442 MW

Protein Function :

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK (By similarity).

Subcellular Localization :

Membrane ; Single-pass type III membrane protein.

Tissue Specificity :

Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.

Background :

TNFRSF17 (Tumor necrosis factor receptor superfamily member 17), also called BCMA, is a protein that in humans is encoded by the TNFRSF17 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily and is mapped to 16p13.13. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

Research Category :

Antiviral Signaling, Cancer, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Signal Transduction