Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody

catalog :

M00971

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

HGI-8

reactivity :

human

application :

western blot, immunocytochemistry

product information

SKU :

M00971

Product Name :

Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

HGI-8

Host :

Rabbit

Reactivity :

Human

Application(s) :

IF, ICC, WB

Application Details :

WB 1:1000-1:2000 .ICC/IF 1:50-1:200

Description :

Boster Bio Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody catalog # M00971. Tested in IF, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

HDAC4

Uniprot ID :

P56524

Immunogen :

A synthesized peptide derived from human HDAC4

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Histone deacetylase 4

Synonyms :

Histone deacetylase 4; HD4; 3.5.1.98; HDAC4; KIAA0288;

Molecular Weight :

119040 MW

Protein Function :

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Subcellular Localization :

Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.

Tissue Specificity :

Ubiquitous.

Research Category :

Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells