Anti-Cystatin C/CST3 Antibody Picoband™ (monoclonal, 8H7)

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Cystatin C/CST3 Antibody Picoband™ (monoclonal, 8H7)

catalog :

M00961-3

quantity :

100µg/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8H7

reactivity :

human

product information

SKU :

M00961-3

Product Name :

Anti-Cystatin C/CST3 Antibody Picoband™ (monoclonal, 8H7)

Size :

100µg/vial

Clonality :

Monoclonal

Clone Number :

8H7

Host :

Mouse

Reactivity :

Human

Application(s) :

ELISA

Application Details :

ELISA (Cap), 1-5µg/ml.

Description :

Boster Bio Anti-Cystatin C/CST3 Antibody Picoband™ (monoclonal, 8H7) catalog # M00961-3. Tested in ELISA applications. This antibody reacts with Human.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

CST3

Uniprot ID :

P01034

Immunogen :

E. coli-derived human Cystatin C recombinant protein (Position: K31-A146).

Form :

Lyophilized

Contents :

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Cross-reactivity :

No cross reactivity with other proteins.

Isotype :

IgG1

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500µg/ml.

Gene Full Name :

cystatin C

Synonyms :

Nuclear factor 1 A-type; NF1-A; Nuclear factor 1/A; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/A; NF-I/A; NFI-A; TGGCA-binding protein; NFIA; KIAA1439

Protein Function :

As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

Subcellular Localization :

Nucleus

Tissue Specificity :

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.

Background :

Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family.

Research Category :

Apoptosis, Atherosclerosis, Cardiovascular, Caspases Etc, Cell Biology, Cell Type Markers, Intracellular, Neural Stem Cells, Stem Cells, Tags & Cell Markers, Tumor Associated