Anti-CD163 Rabbit Monoclonal Antibody | Boster M00812 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-CD163 Rabbit Monoclonal Antibody

catalog :

M00812

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

ABCC-3

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

product information

SKU :

M00812

Product Name :

Anti-CD163 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

ABCC-3

Host :

Rabbit

Reactivity :

Human

Application(s) :

IP, IHC, WB

Application Details :

WB 1:500-1:2000 .IHC 1:50-1:200 .IP 1:30

Description :

Boster Bio Anti-CD163 Rabbit Monoclonal Antibody catalog # M00812. Tested in IP, IHC, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CD163

Uniprot ID :

Q86VB7

Immunogen :

A synthesized peptide derived from human CD163

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Scavenger receptor cysteine-rich type 1 protein M130

Synonyms :

Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor; CD163; Soluble CD163; sCD163; CD163; M130;

Molecular Weight :

125451 MW

Protein Function :

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

Subcellular Localization :

Soluble CD163: Secreted.

Tissue Specificity :

Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Research Category :

Atherosclerosis, Cardiovascular, Cell Type Markers, Immunology, Innate Immunity, Macrophage / Inflamm., Vascular Inflammation