Anti-TGF beta Receptor II TGFBR2 Rabbit Monoclonal Antibody

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-TGF beta Receptor II TGFBR2 Rabbit Monoclonal Antibody

catalog :

M00759

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

ABFE-20

reactivity :

human, mouse, rat

application :

western blot

product information

SKU :

M00759

Product Name :

Anti-TGF beta Receptor II TGFBR2 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

ABFE-20

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

Application Details :

WB 1:500-1:2000

Description :

Boster Bio Anti-TGF beta Receptor II TGFBR2 Rabbit Monoclonal Antibody catalog # M00759. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

TGFBR2

Uniprot ID :

P37173

Immunogen :

A synthesized peptide derived from human TGF beta Receptor II

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

TGF-beta receptor type-2

Synonyms :

TGF-beta receptor type-2; TGFR-2; 2.7.11.30; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2;

Molecular Weight :

64568 MW

Protein Function :

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein.

Research Category :

Nuclear Signaling, Protein Phosphorylation, Ser / Thr Kinases, Signal Transduction, Signaling Pathway, Signaling Pathways, Stem Cells, Surface Molecules, Tgf Beta