Anti-Apolipoprotein A I APOA1 Antibody Picoband™ (monoclonal, 17G5)

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Apolipoprotein A I APOA1 Antibody Picoband™ (monoclonal, 17G5)

catalog :

M00717-1

quantity :

100µg/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

17G5

reactivity :

human

product information

SKU :

M00717-1

Product Name :

Anti-Apolipoprotein A I APOA1 Antibody Picoband™ (monoclonal, 17G5)

Size :

100µg/vial

Clonality :

Monoclonal

Clone Number :

17G5

Host :

Mouse

Reactivity :

Human

Application(s) :

ELISA

Application Details :

ELISA (Cap), 1-5µg/ml.

Description :

Boster Bio Anti-Apolipoprotein A I APOA1 Antibody Picoband™ (monoclonal, 17G5) catalog # M00717-1. Tested in ELISA applications. This antibody reacts with Human.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

APOA1

Uniprot ID :

P02647

Immunogen :

E. coli-derived mouse Apolipoprotein A I recombinant protein (Position: D25-Q264). Mouse Apolipoprotein A I shares 64% and 68.6% amino acid (aa) sequence identity with human and rat Apolipoprotein A I, respectively.

Form :

Lyophilized

Contents :

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Affinity-chromatography

Cross-reactivity :

No cross reactivity with other proteins.

Isotype :

IgG1

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500µg/ml.

Gene Full Name :

apolipoprotein A1

Synonyms :

Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1; Proapolipoprotein A-I; ProapoA-I; Truncated apolipoprotein A-I; Apolipoprotein A-I (1-242); APOA1

Protein Function :

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Subcellular Localization :

Secreted.

Tissue Specificity :

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.

Recommended Detection Systems :

Boster provides a series of assays reacted with primary antibodies.

Background :

Apolipoprotein A-1, also known as APOA1, is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. And it is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The ApoA-I protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I is also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Additionally, ApoA-I overexpression promotes macrophage-specific reverse cholesterol transport.

Research Category :

G Protein Signaling, Signal Transduction, Signaling Pathway