Anti-SIRT6 Rabbit Monoclonal Antibody | Boster M00611 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-SIRT6 Rabbit Monoclonal Antibody

catalog :

M00611

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

HBA-19

reactivity :

human

application :

western blot

product information

SKU :

M00611

Product Name :

Anti-SIRT6 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

HBA-19

Host :

Rabbit

Reactivity :

Human

Application(s) :

Application Details :

WB 1:1000-1:2000

Description :

Boster Bio Anti-SIRT6 Rabbit Monoclonal Antibody catalog # M00611. Tested in WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

SIRT6

Uniprot ID :

Q8N6T7

Immunogen :

A synthesized peptide derived from human SIRT6

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

NAD-dependent protein deacetylase sirtuin-6

Synonyms :

NAD-dependent protein deacetylase sirtuin-6; 3.5.1.-; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; SIRT6; SIR2L6;

Molecular Weight :

39119 MW

Protein Function :

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD (+) in the absence of acetylated substrate.

Subcellular Localization :

Nucleus, nucleoplasm. Predominantly nuclear. Associated with telomeric heterochromatin regions.

Research Category :

Acetylation, Apoptosis, Atherosclerosis, Cancer, Cardiovascular, ChIP’ing Antibodies, Chromatin Modifying Enzymes, Diabetes Associated, Epigenetics and Nuclear Signaling, Metabolism, Nfkb Pathway, Nuclear Signaling Pathways, Obesity, Signal Transduction