Anti-Ms CD26 Purified Dpp4 Monoclonal Antibody | Boster M00597-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Ms CD26 Purified Dpp4 Monoclonal Antibody

catalog :

M00597-1

quantity :

0.1 mg (C100)

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

H194-112

The same clone is also sold as:

BioLegend: 137802, 137805, 137806, 137803, 137813, 137807, 137810, 137815, 137811, 137809, 137801, 137804

reactivity :

mouse

application :

immunohistochemistry, immunoprecipitation, flow cytometry

product information

SKU :

M00597-1

Product Name :

Anti-Ms CD26 Purified Dpp4 Monoclonal Antibody

Size :

0.1 mg (C100)

Clonality :

Monoclonal

Clone Number :

H194-112

Host :

Rat

Reactivity :

Mouse

Application(s) :

IP, Flow Cytometry, IHC

Description :

Boster Bio Anti-Ms CD26 Purified Dpp4 Monoclonal Antibody catalog # M00597-1. Tested in Flow Cytometry, IP, IHC applications. This antibody reacts with Mouse.

Concentration :

1 mg/ml

Gene Name :

Dpp4

Uniprot ID :

P28843

Immunogen :

BALB/c thymocytes

Form :

Liquid

Contents :

Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Purification :

Purified by protein-A affinity chromatography

Isotype :

Rat IgG2a kappa

Storage :

Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.

Gene Full Name :

Toll-like receptor 2

Synonyms :

Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282; TLR2; TIL4;

Protein Name :

Toll-like receptor 2

Molecular Weight :

89838 MW

Protein Function :

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).

Subcellular Localization :

Membrane

Tissue Specificity :

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.