Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody

catalog :

M00587

quantity :

100 ug/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ITGB3/1713

The same clone is also sold as:

Abcam: ab218435
Abnova: MAB14825, MAB14569

reactivity :

human

application :

immunohistochemistry

product information

SKU :

M00587

Product Name :

Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody

Size :

100 ug/vial

Clonality :

Monoclonal

Clone Number :

ITGB3/1713

Host :

Mouse

Reactivity :

Human

Application(s) :

IHC

Application Details :

Immunohistology (Frozen & Formalin-fixed) (1-2ug/ml for 30 minutes at RT).Immunofluorescence (0.5-1ug/ml)

Description :

Boster Bio Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody catalog # M00587. Tested in IHC applications. This antibody reacts with Human.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

ITGB3

Uniprot ID :

P05106

Immunogen :

Recombinant human ITGB3 protein

Form :

Liquid

Contents :

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Purification :

Protein A/G

Isotype :

IgG1, kappa

Storage :

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Gene Full Name :

Integrin beta-3

Synonyms :

Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD61; ITGB3; GP3A;

Molecular Weight :

87058 MW

Protein Function :

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subcellular Localization :

Cell membrane ; Single- pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion.

Tissue Specificity :

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Research Category :

Cell Adhesion, Cell Cycle, Chromosome Structure, Co-Activators/Co-Repressors, Cytoskeleton / Ecm, Epigenetics and Nuclear Signaling, Integrins, Nfkb Pathway, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway