Anti-Human CASR DyLight® 488 conjugated Antibody(monoclonal, 11E9)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Human CASR DyLight® 488 conjugated Antibody(monoclonal, 11E9)

catalog :

M00574-Dyl488

quantity :

50 ug/vial

clonality :

monoclonal

host :

mouse

conjugate :

DyLight488

clone name :

11000000000

reactivity :

human

application :

flow cytometry

product information

SKU :

M00574-Dyl488

Product Name :

Anti-Human CASR DyLight® 488 conjugated Antibody(monoclonal, 11E9)

Size :

50 ug/vial

Clonality :

Monoclonal

Clone Number :

11000000000

Host :

Mouse

Conjugate :

DyLight®488

Reactivity :

Human

Application(s) :

Flow Cytometry

Application Details :

Flow Cytometry, 1-3μg/1x10^6 cells

Description :

Boster Bio Anti-Human CASR DyLight® 488 conjugated Antibody (monoclonal, 11E9) catalog # M00574-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CASR

Uniprot ID :

P41180

Immunogen :

E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

Form :

Liquid

Contents :

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Cross-reactivity :

No cross reactivity with other proteins.

Isotype :

IgG2b

Storage :

At 2-8?C for one year from date of receipt. Protect from light. Do not freeze.

Gene Full Name :

calcium sensing receptor

Synonyms :

Extracellular calcium-sensing receptor; CaR

Protein Function :

G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:7759551). The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).

Subcellular Localization :

Cell membrane

Tissue Specificity :

Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.

Background :

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Research Category :

Calcium Signaling, Cancer, Cofactors, Vitamins / Minerals, Cytoskeleton / Ecm, Extracellular Matrix, G Protein Signaling, Growth Factors/Hormones, Lipid Signaling, Metabolism, Neuroscience, Neurotransmission, Pathways And Processes, Receptors / Channels, Signal Transduction, Signaling Pathway, Structures, Vitamins / Minerals