Anti-CD45 PTPRC Rabbit Monoclonal Antibody | Boster M00555-1 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-CD45 PTPRC Rabbit Monoclonal Antibody

catalog :

M00555-1

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

CBI-16

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry

product information

SKU :

M00555-1

Product Name :

Anti-CD45 PTPRC Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

CBI-16

Host :

Rabbit

Reactivity :

Human

Application(s) :

Flow Cytometry, IHC, WB

Application Details :

WB 1:1000-1:2000 .IHC 1:50-1:200 .Flow Cytometry 1:20

Description :

Boster Bio Anti-CD45 PTPRC Rabbit Monoclonal Antibody catalog # M00555-1. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

PTPRC

Uniprot ID :

P08575

Immunogen :

A synthesized peptide derived from human CD45

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Receptor-type tyrosine-protein phosphatase C

Synonyms :

Receptor-type tyrosine-protein phosphatase C; 3.1.3.48; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45;

Molecular Weight :

147254 MW

Protein Function :

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Subcellular Localization :

Membrane ; Single-pass type I membrane protein. Membrane raft. Colocalized with DPP4 in membrane rafts.

Research Category :

Adapters, Adaptive Immunity, B Cells, Cell Type Markers, Immunology, Protein Phosphorylation, Signal Transduction, T Cells, Transmembrane, Tyrosine Phosphatases