Anti-MERTK/Mer Rabbit Monoclonal Antibody | Boster M00489 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-MERTK/Mer Rabbit Monoclonal Antibody

catalog :

M00489

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

COI-13

The same clone is also sold as:

Abnova: MAB20485

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

product information

SKU :

M00489

Product Name :

Anti-MERTK/Mer Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

COI-13

Host :

Rabbit

Reactivity :

Human

Application(s) :

IP, IHC, WB

Application Details :

WB 1:1000-1:2000 .IHC 1:50-1:200 .IP 1:50

Description :

Boster Bio Anti-MERTK/Mer Rabbit Monoclonal Antibody catalog # M00489. Tested in IP, IHC, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

MERTK

Uniprot ID :

Q12866

Immunogen :

A synthesized peptide derived from human MERTK

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Tyrosine-protein kinase Mer

Synonyms :

Tyrosine-protein kinase Mer; 2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; MERTK; MER;

Molecular Weight :

110249 MW

Protein Function :

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Subcellular Localization :

Membrane ; Single-pass type I membrane protein.

Tissue Specificity :

Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

Research Category :

Intracellular Signaling, Kinases, Neuroscience, Neurotransmission, Protein Phosphorylation, Receptor Tyrosine Kinases, Sensory System, Signal Transduction, Tyrosine Kinases, Visual System