Anti-Ms CD18 Purified Itgb2 Monoclonal Antibody | Boster M00458-3 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Ms CD18 Purified Itgb2 Monoclonal Antibody

catalog :

M00458-3

quantity :

0.1 mg (C100)

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

M18/2

The same clone is also sold as:

Exbio: 12-623-C100, 11-623-C100, 1F-623-C100
Abcam: ab119830
Bio X Cell: BE0009-25MG, BE0009-100MG, BE0009-5MG, BE0009-1MG, BE0009-50MG
Invitrogen: 11-0181-82, 14-0181-85, MA1-10122, 16-0181-81, 13-0181-82, 14-0181-82, 14-0181-81, 11-0181-85, 12-0181-82, MA1-10124
BioLegend: 101419, 101414, 101422, 101421, 101416, 101420, 101408, 101405, 101418, 101407, 101401, 101417, 101402
Santa Cruz Biotechnology: sc-18862 L, sc-18862
Abnova: MAB7917, MAB9797
Novus Biologicals: NBP1-41272

reactivity :

mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

product information

SKU :

M00458-3

Product Name :

Anti-Ms CD18 Purified Itgb2 Monoclonal Antibody

Size :

0.1 mg (C100)

Clonality :

Monoclonal

Clone Number :

M18/2

Host :

Rat

Reactivity :

Mouse

Application(s) :

Flow Cytometry, IP, WB, IHC

Application Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-Ms CD18 Purified Itgb2 Monoclonal Antibody catalog # M00458-3. Tested in Flow Cytometry, IP, IHC, WB applications. This antibody reacts with Mouse.

Concentration :

1 mg/ml

Gene Name :

Itgb2

Uniprot ID :

P11835

Immunogen :

Murine cytotoxic T cell glycoproteins

Form :

Liquid

Contents :

Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Purification :

Purified by protein-A affinity chromatography

Isotype :

Rat IgG2a

Storage :

Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.

Gene Full Name :

tripartite motif containing 25

Synonyms :

E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147; TRIM25; EFP; RNF147; ZNF147

Protein Function :

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3.

Subcellular Localization :

Cytoplasm

Tissue Specificity :

Expressed in breast tumors (at protein level). Ubiquitous.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P) and ICC.

Background :

Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene. It is mapped to 17q22. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.