Anti-Retinoic Acid Receptor alpha RARA Rabbit Monoclonal Antibody

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Retinoic Acid Receptor alpha RARA Rabbit Monoclonal Antibody

catalog :

M00392

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

GBC-18

reactivity :

human, mouse

application :

western blot, flow cytometry

product information

SKU :

M00392

Product Name :

Anti-Retinoic Acid Receptor alpha RARA Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

GBC-18

Host :

Rabbit

Reactivity :

Human, Mouse

Application(s) :

Flow Cytometry, WB

Application Details :

WB 1:500-1:1000 .Flow Cytometry 1:50

Description :

Boster Bio Anti-Retinoic Acid Receptor alpha RARA Rabbit Monoclonal Antibody catalog # M00392. Tested in WB applications. This antibody reacts with Human, Mouse.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

RARA

Uniprot ID :

P10276

Immunogen :

A synthesized peptide derived from human Retinoic Acid Receptor alpha

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Retinoic acid receptor alpha

Synonyms :

Retinoic acid receptor alpha; RAR-alpha; Nuclear receptor subfamily 1 group B member 1; RARA; NR1B1;

Molecular Weight :

50771 MW

Protein Function :

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand- dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

Subcellular Localization :

Nucleus. Cytoplasm. Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.

Research Category :

Cancer, Cancer Metabolism, Domain Families, Epigenetics and Nuclear Signaling, Metabolism, Metabolism Processes, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Pathways And Processes, Response To Hypoxia, Signal Transduction, Signaling Pathway, Transcription, Zinc Finger