Anti-IL-2 Monoclonal Antibody | Boster M00387 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-IL-2 Monoclonal Antibody

catalog :

M00387

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8D5

The same clone is also sold as:

Abnova: MAB10421
OriGene: AM06310SU-N
Invitrogen: MA5-17097

reactivity :

human

application :

western blot, ELISA

product information

SKU :

M00387

Product Name :

Anti-IL-2 Monoclonal Antibody

Size :

100 ul

Clonality :

Monoclonal

Clone Number :

8D5

Host :

Mouse

Reactivity :

Human

Application(s) :

WB, ELISA

Application Details :

WB 1:500-1:2000 ELISA 1:10000

Description :

Boster Bio Anti-IL-2 Monoclonal Antibody catalog # M00387. Tested in ELISA, WB applications. This antibody reacts with Human.

Concentration :

1 mg/ml

Gene Name :

IL2

Uniprot ID :

P60568

Immunogen :

Purified recombinant fragment of IL-2 expressed in E. Coli.

Form :

Liquid

Contents :

Ascitic fluid containing 0.03% sodium azide.

Purification :

Affinity purification

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Tumor protein 63

Synonyms :

Tumor protein 63; p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51; TP63; KET, P63, P73H, P73L, TP73L;

Protein Name :

Tumor protein 63

Molecular Weight :

76785 MW

Protein Function :

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Subcellular Localization :

Nucleus

Tissue Specificity :

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.