Anti-CD46 Rabbit Monoclonal Antibody | Boster M00377-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-CD46 Rabbit Monoclonal Antibody

catalog :

M00377-1

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

AEI-3

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

product information

SKU :

M00377-1

Product Name :

Anti-CD46 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

AEI-3

Host :

Rabbit

Reactivity :

Human

Application(s) :

IF, IHC, ICC, WB

Application Details :

WB 1:500-1:2000 .IHC 1:50-1:200 .ICC/IF 1:50-1:200

Description :

Boster Bio Anti-CD46 Rabbit Monoclonal Antibody catalog # M00377-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CD46

Uniprot ID :

P15529

Immunogen :

A synthesized peptide derived from human CD46

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Membrane cofactor protein

Synonyms :

Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; CD46; CD46; MCP, MIC10;

Molecular Weight :

43747 MW

Protein Function :

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Subcellular Localization :

Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane ; Single- pass type I membrane protein. Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.

Tissue Specificity :

Expressed by all cells except erythrocytes.

Research Category :

Cell Type Markers, Complement, Immunology, Innate Immunity