Anti-Elafin/Skalp PI3 Antibody Picoband™ (monoclonal, C7)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Elafin/Skalp PI3 Antibody Picoband™ (monoclonal, C7)

catalog :

M00364

quantity :

100µg/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C7

The same clone is also sold as:

Invitrogen: MA5-27876

reactivity :

human

application :

immunohistochemistry

product information

SKU :

M00364

Product Name :

Anti-Elafin/Skalp PI3 Antibody Picoband™ (monoclonal, C7)

Size :

100µg/vial

Clonality :

Monoclonal

Clone Number :

Host :

Mouse

Reactivity :

Human

Application(s) :

ELISA, IHC

Application Details :

Immunohistochemistry (Paraffin-embedded Section), 0.5-1µg/ml. ELISA (Cap), 1-5µg/ml

Description :

Boster Bio Anti-Elafin/Skalp PI3 Antibody Picoband™ (monoclonal, C7) catalog # M00364. Tested in ELISA, IHC applications. This antibody reacts with Human.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

PI3

Uniprot ID :

P19957

Immunogen :

E. coli-derived human Elafin/Skalp recombinant protein (Position: A61-Q117).

Form :

Lyophilized

Contents :

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Cross-reactivity :

No cross reactivity with other proteins.

Isotype :

IgG1

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Gene Full Name :

peptidase inhibitor 3

Synonyms :

Elafin; Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14; PI3; WAP3; WFDC14

Protein Function :

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

Subcellular Localization :

Secreted.

Recommended Detection Systems :

Boster recommends HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P).

Background :

Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene. This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. And this gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.

Research Category :

Cell Biology, Cell Cycle, Immunology, Innate Immunity, Kinases/Phosphatases, Lipid Signaling, Protein Phosphorylation, Ser / Thr Kinases, Signal Transduction, Signaling Pathway, Tlr Signaling