Anti-ATG7/Apg7 Rabbit Monoclonal Antibody | Boster M00346 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-ATG7/Apg7 Rabbit Monoclonal Antibody

catalog :

M00346

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

FCA-1

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

product information

SKU :

M00346

Product Name :

Anti-ATG7/Apg7 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

FCA-1

Host :

Rabbit

Reactivity :

Human

Application(s) :

Flow Cytometry, IP, IF, IHC, ICC, WB

Application Details :

WB 1:10000-1:50000 .IHC 1:50-1:200 .ICC/IF 1:50-1:200 .IP 1:20 .Flow Cytometry 1:20

Description :

Boster Bio Anti-ATG7/Apg7 Rabbit Monoclonal Antibody catalog # M00346. Tested in Flow Cytometry, IP, IF, IHC, ICC, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

ATG7

Uniprot ID :

O95352

Immunogen :

A synthesized peptide derived from human ATG7

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Ubiquitin-like modifier-activating enzyme ATG7

Synonyms :

Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein; ATG7; APG7L;

Molecular Weight :

77960 MW

Protein Function :

E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Subcellular Localization :

Cytoplasm. Preautophagosomal structure. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.

Tissue Specificity :

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.

Research Category :

Apoptosis, Associated Proteins, Cancer, Cardiovascular, Cell Biology, Cell Death, Energy Metabolism, Energy Transfer Pathways, Intracellular, Metabolic Signaling Pathways, Metabolism, Metabolism Processes, Mitochondrial Metabolism, Pathways And Processes, Proteasome / Ubiquitin, Proteolysis / Ubiquitin, Signal Transduction, Ub-Like Proteins