Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250 | Boster M00334-8 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250

catalog :

M00334-8

quantity :

100 ul

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM250

The same clone is also sold as:

Abnova: MAB14911

reactivity :

human

application :

western blot, immunohistochemistry

product information

SKU :

M00334-8

Product Name :

Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250

Size :

100 ul

Clonality :

Monoclonal

Clone Number :

RM250

Host :

Rabbit

Reactivity :

Human

Application(s) :

WB, IHC

Application Details :

Immunohistochemistry (IHC): 1:1000-1:2500 dilution; Western Blot (WB): 1:1000-1:2000 dilution.

Description :

Boster Bio Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250 catalog # M00334-8. Tested in IHC, WB applications. This antibody reacts with Human.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CASP3

Uniprot ID :

P42574

Immunogen :

A synthetic peptide corresponding to residues within human Caspase-3 subunit p17

Contents :

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Caspase-3

Synonyms :

Caspase-3; CASP-3; 3.4.22.56; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1; Caspase-3 subunit p17; Caspase-3 subunit p12; CASP3; CPP32;

Molecular Weight :

31608 MW

Protein Function :

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Subcellular Localization :

Cytoplasm

Tissue Specificity :

Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Research Category :

Alzheimer'S Disease, Apoptosis, Apoptotic Markers, Cancer, Caspases Etc, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Neurodegenerative Disease, Neurology Process, Neuroscience