Anti-Stromal interaction molecule 1 STIM1 Rabbit Monoclonal Antibody

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Stromal interaction molecule 1 STIM1 Rabbit Monoclonal Antibody

catalog :

M00312

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

HEC-19

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

product information

SKU :

M00312

Product Name :

Anti-Stromal interaction molecule 1 STIM1 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

HEC-19

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

IP, IHC, WB

Application Details :

WB 1:1000-1:2000 .IHC 1:50-1:200 .IP 1:50

Description :

Boster Bio Anti-Stromal interaction molecule 1 STIM1 Rabbit Monoclonal Antibody catalog # M00312. Tested in IP, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

STIM1

Uniprot ID :

Q13586

Immunogen :

A synthesized peptide derived from human Stromal interaction molecule 1

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Stromal interaction molecule 1

Synonyms :

Stromal interaction molecule 1; STIM1; GOK;

Molecular Weight :

77423 MW

Protein Function :

Plays a role in mediating store-operated Ca (2+) entry (SOCE), a Ca (2+) influx following depletion of intracellular Ca (2+) stores. Acts as Ca (2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca (2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca (2+) release-activated Ca (2+) (CRAC) channel subunit, TMEM142A/ORAI1. Involved in enamel formation.

Subcellular Localization :

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules.

Tissue Specificity :

Ubiquitously expressed in various human primary cells and tumor cell lines.

Research Category :

Calcium Channels, Calcium Signaling, Cancer, Metabolism, Plasma Membrane, Signal Transduction, Signaling Pathway