Anti-Ki 67 MKI67 Monoclonal Antibody | Boster M00254-7 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Ki 67 MKI67 Monoclonal Antibody

catalog :

M00254-7

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A8

reactivity :

human

application :

immunohistochemistry

product information

SKU :

M00254-7

Product Name :

Anti-Ki 67 MKI67 Monoclonal Antibody

Size :

100 ul

Clonality :

Monoclonal

Clone Number :

4A8

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Application(s) :

IHC

Application Details :

IHC 1:200

Description :

Boster Bio Anti-Ki 67 MKI67 Monoclonal Antibody catalog # M00254-7. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

1 mg/ml

Gene Name :

MKI67

Uniprot ID :

P46013

Immunogen :

Synthetic Peptide

Form :

Liquid

Contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification :

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Breast cancer type 1 susceptibility protein

Synonyms :

Breast cancer type 1 susceptibility protein; 2.3.2.27

Protein Name :

Breast cancer type 1 susceptibility protein

Molecular Weight :

207721 MW

Protein Function :

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719).

Subcellular Localization :

Nucleus

Tissue Specificity :

Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.