Anti-ACE1 Monoclonal Antibody | Boster M00251-2 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-ACE1 Monoclonal Antibody

catalog :

M00251-2

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

monoclonal

reactivity :

human

application :

western blot

product information

SKU :

M00251-2

Product Name :

Anti-ACE1 Monoclonal Antibody

Size :

100 ul

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse, Rat, Bovine

Application(s) :

Application Details :

WB 1:1000-1:2000

Description :

Boster Bio Anti-ACE1 Monoclonal Antibody catalog # M00251-2. Tested in WB applications. This antibody reacts with Bovine, Human, Mouse, Rat.

Concentration :

1 mg/ml

Gene Name :

ACE

Uniprot ID :

P12821

Immunogen :

Purified recombinant human ACE1 (N-terminal) protein fragments expressed in E.coli.

Form :

Liquid

Contents :

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Purification :

Affinity purification

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Mitogen-activated protein kinase 8

Synonyms :

Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; 2.7.11.24

Protein Name :

Mitogen-activated protein kinase 8

Molecular Weight :

48296 MW

Protein Function :

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity).

Subcellular Localization :

Cytoplasm