Anti-PGC1 alpha PPARGC1A Rabbit Monoclonal Antibody | Boster M00236 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-PGC1 alpha PPARGC1A Rabbit Monoclonal Antibody

catalog :

M00236

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

AOBC-16

reactivity :

human, mouse, rat

application :

western blot

product information

SKU :

M00236

Product Name :

Anti-PGC1 alpha PPARGC1A Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

AOBC-16

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

Application Details :

WB 1:500-1:2000

Description :

Boster Bio Anti-PGC1 alpha PPARGC1A Rabbit Monoclonal Antibody catalog # M00236. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

PPARGC1A

Uniprot ID :

Q9UBK2

Immunogen :

A synthesized peptide derived from human PGC1 alpha

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Synonyms :

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6; PPARGC1A; LEM6, PGC1, PGC1A, PPARGC1;

Molecular Weight :

91027 MW

Protein Function :

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Subcellular Localization :

Isoform 1: Nucleus. Nucleus, PML body.

Tissue Specificity :

Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.

Research Category :

Diabetes Associated, Epigenetics and Nuclear Signaling, Fatty Acid Oxidation, Fatty Acids, Heart Disease, Lipid And Lipoprotein Metabolism, Lipids / Lipoproteins, Metabolic Signaling Pathways, Metabolism, Mitochondrial Metabolism, Nuclear Receptors, Nuclear Signaling Pathways, Nucleotide Metabolism, Obesity, Pathways And Processes, Redox Metabolism, Transcription