Anti-Tuberin TSC2 Rabbit Monoclonal Antibody | Boster M00229 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Tuberin TSC2 Rabbit Monoclonal Antibody

catalog :

M00229

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

EGD-20

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, flow cytometry

product information

SKU :

M00229

Product Name :

Anti-Tuberin TSC2 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

EGD-20

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

Flow Cytometry, IHC, WB

Application Details :

WB 1:500-1:2000 .IHC 1:50-1:200 .Flow Cytometry 1:50

Description :

Boster Bio Anti-Tuberin TSC2 Rabbit Monoclonal Antibody catalog # M00229. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

TSC2

Uniprot ID :

P49815

Immunogen :

A synthesized peptide derived from human Tuberin

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Tuberin

Synonyms :

Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4;

Molecular Weight :

200608 MW

Protein Function :

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Subcellular Localization :

Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

Tissue Specificity :

Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

Research Category :

Domain Families, Epigenetics and Nuclear Signaling, Hlh / Leucine Zipper, Transcription, Transcription Factors