Anti-p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) TP63 Antibody

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) TP63 Antibody

catalog :

M00167

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

immunohistochemistry

product information

SKU :

M00167

Product Name :

Anti-p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) TP63 Antibody

Size :

100 ug/vial

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Bovine, Rat, Mouse, Human

Application(s) :

IHC

Application Details :

Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT).Immunofluorescence (1-2ug/ml)

Description :

Boster Bio Anti-p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) TP63 Antibody catalog # M00167. Tested in IHC applications. This antibody reacts with Bovine, Human, Mouse, Rat.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

TP63

Uniprot ID :

Q9H3D4

Immunogen :

A synthetic peptide (ENNAQTQFSEPQY) corresponding to aa5-17 of human p40

Form :

Liquid

Contents :

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Purification :

protein A

Isotype :

IgG

Storage :

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Gene Full Name :

Tumor protein 63

Synonyms :

Tumor protein 63; p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51; TP63; KET, P63, P73H, P73L, TP73L;

Molecular Weight :

76785 MW

Protein Function :

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Subcellular Localization :

Nucleus.

Tissue Specificity :

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.

Research Category :

Apoptosis, Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, DNA / RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling, Intracellular, Oncoproteins/Suppressors, P53 Pathway, Transcription, Tumor Suppressors