Anti-Dnmt3a Rabbit Monoclonal Antibody | Boster M00136 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Dnmt3a Rabbit Monoclonal Antibody

catalog :

M00136

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

EOI-4

reactivity :

human, rat

application :

western blot, immunocytochemistry

product information

SKU :

M00136

Product Name :

Anti-Dnmt3a Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

EOI-4

Host :

Rabbit

Reactivity :

Human, Rat

Application(s) :

IF, ICC, WB

Application Details :

WB 1:500-1:2000 .ICC/IF 1:100-1:500

Description :

Boster Bio Anti-Dnmt3a Rabbit Monoclonal Antibody catalog # M00136. Tested in IF, ICC, WB applications. This antibody reacts with Human, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

DNMT3A

Uniprot ID :

Q9Y6K1

Immunogen :

A synthesized peptide derived from human Dnmt3a

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

DNA (cytosine-5)-methyltransferase 3A

Synonyms :

DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; 2.1.1.37; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA; DNMT3A;

Molecular Weight :

101858 MW

Protein Function :

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

Subcellular Localization :

Nucleus. Cytoplasm. Accumulates in the major satellite repeats at pericentric heterochromatin.

Tissue Specificity :

Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.

Research Category :

ChIP’ing Antibodies, Epigenetics and Nuclear Signaling