Anti-IL-33 Antibody (Monoclonal, Nessy-1) | Boster M00113 product information

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product summary

company name :

Boster

product type :

other

product name :

Anti-IL-33 Antibody (Monoclonal, Nessy-1)

catalog :

M00113

quantity :

100µg/vial

product information

SKU :

M00113

Product Name :

Anti-IL-33 Antibody (Monoclonal, Nessy-1)

Size :

100µg/vial

Clonality :

Monoclonal

Clone Number :

12B3C4

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Application(s) :

IP, IHC

Application Details :

IP, 1:100, Human, Mouse, Rat

Description :

Boster Bio Anti-IL-33 Antibody (Monoclonal, Nessy-1) catalog # M00113. Tested in IP, IHC applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

1 mg/mL

Gene Name :

IL33

Uniprot ID :

O95760

Immunogen :

Recombinant human IL-33 (aa 112-270).

Form :

Liquid

Contents :

In PBS.

Purification :

Protein G-affinity purified.

Isotype :

Mouse IgG1

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Interleukin-33

Synonyms :

Interleukin-33; IL-33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV; Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270); IL33; C9orf26, IL1F11, NFHEV;

Protein Name :

Interleukin-33 (IL33)

Molecular Weight :

30759 MW

Protein Function :

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).

Subcellular Localization :

Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.

Tissue Specificity :

Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.

Background :

Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. The IL33 gene maps to chromosome 9p24.1 by using of genomic database analysis. Recombinant mature human IL33 bound to ST2. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33. IL33, an alarmin released from necrotic cells, is necessary for potent CD8 + T cell (CTL) responses to replicating, prototypic RNA, and DNA viruses in mice. IL33 prevented the downregulation of CXCR2 and inhibition of chemotaxis induced by activation of TLR4, and found that IL33 reverses the TLR4-induced reduction of CXCR2 expression via the inhibition of expression of GRK2.

Research Category :

Angiogenesis, Cardiovascular, Cytokines, Hypertrophy, Immunology, Innate Immunity, Interleukins