Anti-COX2 PTGS2 Monoclonal Antibody | Boster M00084-3 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-COX2 PTGS2 Monoclonal Antibody

catalog :

M00084-3

quantity :

100 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D4

reactivity :

human, mouse, rat

application :

immunohistochemistry

product information

SKU :

M00084-3

Product Name :

Anti-COX2 PTGS2 Monoclonal Antibody

Size :

100 ul

Clonality :

Monoclonal

Clone Number :

3D4

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Application(s) :

IHC

Application Details :

IHC 1:200

Description :

Boster Bio Anti-COX2 PTGS2 Monoclonal Antibody catalog # M00084-3. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

1 mg/ml

Gene Name :

PTGS2

Uniprot ID :

P35354

Immunogen :

Synthetic Peptide

Form :

Liquid

Contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification :

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Glutamate receptor ionotropic, NMDA 2B

Synonyms :

Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B

Protein Name :

Glutamate receptor ionotropic, NMDA 2B

Molecular Weight :

166367 MW

Protein Function :

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg (2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).

Subcellular Localization :

Cell membrane

Tissue Specificity :

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.