Anti-CD44 Rabbit Monoclonal Antibody, Clone#RM264 | Boster M00052-2 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-CD44 Rabbit Monoclonal Antibody, Clone#RM264

catalog :

M00052-2

quantity :

100 uL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM264

The same clone is also sold as:

Abnova: MAB15138

reactivity :

human

application :

western blot, immunohistochemistry

product information

SKU :

M00052-2

Product Name :

Anti-CD44 Rabbit Monoclonal Antibody, Clone#RM264

Size :

100 uL

Clonality :

Monoclonal

Clone Number :

RM264

Host :

Rabbit

Reactivity :

Human

Application(s) :

WB, IHC

Application Details :

Immunohistochemistry (IHC): 1:1000-1:5000 dilution; Western Blot (WB): 1:1000-1:2000 dilution.

Description :

Boster Bio Anti-CD44 Rabbit Monoclonal Antibody, Clone#RM264 catalog # M00052-2. Tested in IHC, WB applications. This antibody reacts with Human.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CD44

Uniprot ID :

P16070

Immunogen :

A peptide corresponding to the extracellular domain of human CD44.

Contents :

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

CD44 antigen

Synonyms :

CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD44; CD44; LHR, MDU2, MDU3, MIC4;

Molecular Weight :

81538 MW

Protein Function :

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein. Colocalizes with actin in membrane protrusions at wounding edges.

Tissue Specificity :

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Research Category :

Cancer, Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Mesenchymal Stem Cells, Myeloid, Stem Cells, Surface Molecules, T Lymphocytic Lineage, Tumor Biomarkers, Tumor Immunology