Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

other

product name :

Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody

catalog :

M00010

quantity :

100 ug/vial

product information

sku :

M00010

status :

Enabled

name :

Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody

category name :

Primary Antibodies, Monoclonal Antibodies, IHC ICC IF Antibodies

gene name :

ERBB2

price various sizes :

20ug sample size / $99 100ug / $299 100ug+Free HRP Secondary BA1050 / $299 100ug+Free Biotin Secondary BA1001 / $299

clonality :

Monoclonal

clone number :

ERB2/776

concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

conjugate :

contents :

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

description :

Mouse Monoclonal Antibody [Clone ERB2/776] antibody for Her2/ERBB2 detection. Host: Mouse.Size: 100ug/vial. Tested applications: IF. Reactive species: Human. Her2/ERBB2 information: Molecular Weight: 137910 MW; Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1; Tissue Specificity: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

short description :

Anti-HER-2 / c-erbB-2 / neu / CD340 Antibody

size :

100 ug/vial

sample size available :

20ug for $99, contact us for details

uniprot id :

P04626

host :

Mouse

immunogen :

Recombinant intracellular domain of human HER-2 protein

form :

Liquid

application details :

Immunohistology (Formalin-fixed ) (0.5-1ug/ml for 30 min at Room Temp). Immunofluorescence (0.5-1ug/ml)

applications :

IHC

reactivity :

Human

image labels :

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained withHER-2 Monoclonal Antibody (ERB2/776).

research category :

Cancer, Cell Type Markers, Growth Factors, Growth Factors/Hormones, Oncoproteins, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tags & Cell Markers, Tumor Associated, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens, Tyrosine Kinases

synonyms :

Receptor tyrosine-protein kinase erbB-2;2.7.10.1;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD340;ERBB2;HER2, MLN19, NEU, NGL;

gene full name :

Receptor tyrosine-protein kinase erbB-2

molecular weight :

137910 MW

protein function :

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

subcellular localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.

tissue specificity :

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

last modified :

2/6/19 22:57