Anti-TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody

catalog :

M00002

quantity :

100 ug/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TNF706 + P/T2

The same clone is also sold as:

OriGene: AM50318PU-S, AM50318PU-T
MyBioSource: MBS438365
Abcam: ab212899

reactivity :

human, mouse, rat, dogs

application :

immunohistochemistry

product information

SKU :

M00002

Product Name :

Anti-TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody

Size :

100 ug/vial

Clonality :

Monoclonal

Clone Number :

TNF706 + P/T2

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rabbit, Rat

Application(s) :

IHC

Application Details :

Immunohistology (Formalin-paraffin) (2-4ug/ml for 30 min at RT).Immunofluorescence (1-2ug/ml)

Description :

Boster Bio Anti-TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody catalog # M00002. Tested in IHC applications. This antibody reacts with Canine, Human, Mouse, Rabbit, Rat.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

TNF

Uniprot ID :

P01375

Immunogen :

Recombinant N-terminal fragment of human TNF-? (TNF706); Peptide corresponding to aa115-130 of human TNF-? (P/T2)

Form :

Liquid

Contents :

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Purification :

Bioreactor Concentrate

Isotype :

IgM, kappa

Storage :

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Gene Full Name :

Tumor necrosis factor

Synonyms :

Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Tumor necrosis factor, membrane form; N-terminal fragment; NTF; Intracellular domain 1; ICD1; Intracellular domain 2; ICD2; C-domain 1; C-domain 2; Tumor necrosis factor, soluble form; TNF; TNFA, TNFSF2;

Molecular Weight :

25644 MW

Protein Function :

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).

Subcellular Localization :

Cell membrane ; Single-pass type II membrane protein.

Research Category :

Atherosclerosis, Cancer, Cardiovascular, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Metabolism, Signal Transduction, Tnf Superfamily, Vascular Inflammation