Anti-P53 Antibody | Boster M00001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-P53 Antibody

catalog :

M00001

quantity :

50 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

monoclonal

reactivity :

human

application :

western blot

product information

SKU :

M00001

Product Name :

Anti-P53 Antibody

Size :

50 ul

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, African green monkey

Application(s) :

Application Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-P53 Antibody catalog # M00001. Tested in WB applications. This antibody reacts with African green monkey, Human.

Gene Name :

TP53

Uniprot ID :

P04637

Immunogen :

This P53 antibody is generated from a mouse immunized with a recombinant protein conjugated synthetic peptide between 1-393 amino acids from human P53.

Contents :

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Isotype :

IgG1,k

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Background :

BRCA1, mapped to 17q21.3, is also known as BRCC1. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. In addition to it, BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth and that this function is compromised in breast cancer either by direct mutation or by alterations in gene expression.